Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations.

TA Bowdle, AD Radant, DS Cowley, ED Kharasch… - …, 1998 - europepmc.org
Ketamine has been associated with a unique spectrum of subjective "psychedelic" effects
in … This study quantified these effects of ketamine and related them to steady-state plasma

Ketamine psychedelic and antinociceptive effects are connected

E Olofsen, J Kamp, TK Henthorn, M van Velzen… - …, 2022 - ingentaconnect.com
… the psychedelic effects of ketamine in healthy volunteers. The … - and S-ketamine and
norketamine plasma concentration data. … are comparably potent under steady-state conditions but …

Studies with psychedelic drugs in human volunteers

EM Sellers, MK Romach, DB Leiderman - Neuropharmacology, 2018 - Elsevier
… from the classical agents to DMT, MDMA, ketamine, … effects decrease much faster than
plasma concentrations and … An interesting adverse effect, seen in this study was a dose related, …

[PDF][PDF] Psychedelic Effects of Ketamine in Healthy Volunteers

ED Kharasch, RJ Strassman, PP Roy-Byrne - Anesthesiology, 1998 - researchgate.net
… has been associated with a unique spectrum of subjective “psychedelic" effects in … these
effects of ketamine and related them to steady-state plasma concentrations. Methods: Ketamine

[PDF][PDF] Inhaled ketamine: evaluation of safety and efficacy in healthy volunteers

K Jonkman, A Duma, M van Velzen, E Olofsen… - scholarlypublications …
… The lower scores are probably related to the lower plasma … with minimal psychedelic effects
or mood related changes. … rapidly produces steady-state esketamine plasma concentrations …

The Effect of a Target Controlled Infusion of Low-Concentration Ketamine on the Heart Rate Variability of Normal Volunteers

JY Jung, JH Lee, JS Lee, YI Kim - The Korean Journal of Pain, 2009 - koreascience.kr
… Bowdle TA, Radant AD, Cowley DS, Kharasch ED, Strassman RJ, Roy-Byrne PP:
Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma con…

[HTML][HTML] Subanaesthetic ketamine and altered states of consciousness in humans

PE Vlisides, T Bel-Bahar, A Nelson, K Chilton… - British journal of …, 2018 - Elsevier
ketamine infusion reached pharmacological steady-state conditions by that point. As part of
a pilot study in human volunteers, we assessed plasmaketamine and other psychedelics. …

[HTML][HTML] Cortical dynamics during psychedelic and anesthetized states induced by ketamine

D Li, GA Mashour - Neuroimage, 2019 - Elsevier
… the ketamine infusion reached pharmacological steady-state … spectral changes, but this
association was largely mitigated for … In this study of human volunteers, we investigated the …

[图书][B] Pharmacokinetics and pharmacodynamics of the psychedelic compund DMT

E Eckernäs - 2023 - gupea.ub.gu.se
… , investigating the effects and tolerability in healthy subjects. … the psychedelic effects of DMT
appear to follow the plasma … of a bolus dose as well as at steady-state. The proportions of the …

Population pharmacokinetics of esketamine nasal spray and its metabolite noresketamine in healthy subjects and patients with treatment-resistant depression

C Perez-Ruixo, S Rossenu, P Zannikos, P Nandy… - Clinical …, 2021 - Springer
… Noresketamine volume at steady state and apparent … the plasma concentrations of
esketamine and noresketamine in … –response relationships and guiding the dose selection. …