A large portion of the total energy consumption in any wastewater treatment plant is used for pumping wastewater and sewage within the treatment processes. But the efficient operation of sewage pumps requires an accurate calculation of friction losses for which sludge rheological parameters are involved as a control. This work determines the usual variations of rheological parameters of anaerobic digested sludge, waste activated sludge and primary sludge in a wastewater treatment plant over one year of sampling. The impact of model selection and data fitting on the pressure drop calculation is also investigated. The pressure drop calculation for a sludge pipeline using the novel Re3 model was successfully validated with 10% errors against the site observation. The pressure drop calculations for higher solid concentration suggested high variations of pressure drop, which requires further study.