[HTML][HTML] Pyrazolo [3, 4-d] pyrimidine based scaffold derivatives targeting kinases as anticancer agents
NSM Ismail, EMH Ali, DA Ibrahim, RAT Serya… - Future Journal of …, 2016 - Elsevier
Future Journal of Pharmaceutical Sciences, 2016•Elsevier
Pyrazolopyrimidines are fused heterocyclic ring systems which structurally can consider as
bioisosteres of adenine, which is fundamental for every aspect of cell life. Pyrazolo [3, 4-d]
pyrimidines derivatives have been explored for their inhibitory activity towards various
protein kinase enzymes and their role as anticancer agents. The present review to the best
of our knowledge is the first compilation on synthesis and medicinal aspects including
structure–activity relationships of pyrazolo [3, 4-d] pyrimidines reported to date.
bioisosteres of adenine, which is fundamental for every aspect of cell life. Pyrazolo [3, 4-d]
pyrimidines derivatives have been explored for their inhibitory activity towards various
protein kinase enzymes and their role as anticancer agents. The present review to the best
of our knowledge is the first compilation on synthesis and medicinal aspects including
structure–activity relationships of pyrazolo [3, 4-d] pyrimidines reported to date.
Abstract
Pyrazolopyrimidines are fused heterocyclic ring systems which structurally can consider as bioisosteres of adenine, which is fundamental for every aspect of cell life. Pyrazolo[3,4-d]pyrimidines derivatives have been explored for their inhibitory activity towards various protein kinase enzymes and their role as anticancer agents. The present review to the best of our knowledge is the first compilation on synthesis and medicinal aspects including structure–activity relationships of pyrazolo[3,4-d]pyrimidines reported to date.
Elsevier
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