Electrocardiogram (ECG) is a graphical representation generated by heart muscle. ECG plays an important role in diagnosis and monitoring of heart’s condition. The real time analyzer based on filtering, beat recognition, clustering, classification of signal with maximum few seconds delay can be done to recognize the life threatening arrhythmia. ECG signal examines and study of anatomic and physiologic facets of the entire cardiac muscle. The inceptive task for proficient scrutiny is the expulsion of noise. It is attained by the use of wavelet transform analysis. Wavelets yield temporal and spectral information concurrently and offer stretchability with a possibility of wavelet functions of different properties. This paper is concerned with the extraction of QRS complexes of ECG signals using Discrete Wavelet Transform based algorithms aided with MATLAB. By removing the inconsistent wavelet transform coefficient, denoising is done in ECG signal. In continuation, QRS complexes are identified and in which each peak can be utilized to discover the peak of separate waves like P and T with their derivatives. Here we put forth a new combinatory algorithm builded on using Pan-Tompkins' method and multi-wavelet transform.