Prostate biopsy is the clinical standard for the diagnosis of prostate cancer, and
technologies for 3D guidance to targets and recording of biopsy locations are promising
approaches to reducing the need for repeated biopsies. In this study, we use image-based
non-rigid registration to quantify prostate deformation during needle insertion and biopsy
gun firing, in order to provide information useful to the overall assessment of a TRUS-guided
biopsy system's expected targeting error. We recorded mean tissue displacements of up to …

Purpose: Prostate biopsy is the clinical standard for the definitive diagnosis of prostate
cancer. To overcome the limitations of 2D TRUS‐guided biopsy systems when targeting
preplanned locations, systems have been developed with 3D guidance to improve the
accuracy of cancer detection. Prostate deformation due to needle insertion and biopsy gun
firing is a potential source of error that can cause target misalignments during biopsies.
Methods: The authors used nonrigid registration of 2D TRUS images to quantify the …