Recent genome-wide association studies have linked common variants in the human
genome to Parkinson's disease (PD) risk. Here we show that the consequences of variants
at 2 such loci, PARK16 and LRRK2, are highly interrelated, both in terms of their broad
impacts on human brain transcriptomes of unaffected carriers, and in terms of their
associations with PD risk. Deficiency of the PARK16 locus gene RAB7L1 in primary rodent
neurons, or of a RAB7L1 ortholog in Drosophila dopamine neurons, recapitulated …

2017-05-19 Assigned to THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF
NEW YORK reassignment THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF
NEW YORK ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS).
Assignors: ABELIOVICH, ASA2017-05-19 Assigned to THE TRUSTEES OF COLUMBIA
UNIVERSITY IN THE CITY OF NEW YORK reassignment THE TRUSTEES OF COLUMBIA
UNIVERSITY IN THE CITY OF NEW YORK ASSIGNMENT OF ASSIGNORS INTEREST (SEE …