[PDF][PDF] RIFM fragrance ingredient safety assessment, β-caryophyllene alcohol, CAS Registry Number 472-97-9

AM Api, D Belsito, D Botelho… - Food Chem …, 2018 - fragrancematerialsafetyresource …
AM Api, D Belsito, D Botelho, M Bruze, GA Burton, J Buschmann, ML Dagli, M Date
Food Chem. Toxicol, 2018fragrancematerialsafetyresource …
The use of this material under current conditions is supported by existing information. β-
Caryophyllene alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive
toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and
environmental safety. Data show that β-caryophyllene alcohol is not genotoxic. The skin
sensitization endpoint was completed using the DST for non-reactive materials (900
μg/cm2); exposure is below the DST. The repeated dose, reproductive, and local respiratory …
Summary
The use of this material under current conditions is supported by existing information. β-Caryophyllene alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that β-caryophyllene alcohol is not genotoxic. The skin sensitization endpoint was completed using the DST for non-reactive materials (900 μg/cm2); exposure is below the DST. The repeated dose, reproductive, and local respiratory toxicity endpoints were completed using the TTC for a Cramer Class III material, and the exposure to β-caryophyllene alcohol is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra; β-caryophyllene alcohol is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; β-caryophyllene alcohol was not found to be PBT as per IFRA environmental standards, and its risk quotients, based on its current volume of use in Europe and North America (ie, PEC/PNEC), are< 1.
fragrancematerialsafetyresource.elsevier.com
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