The existing information supports the use of this material as described in this safety assessment.

Citronellal was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that citronellal is not genotoxic. Data on read-across analog citral (CAS# 5392-40-5) provided a calculated margin of exposure (MOE)> 100 for the repeated dose toxicity and the developmental and reproductive toxicity endpoints. For the skin sensitization endpoint, the No Expected Sensitization Induction Level (NESIL) for citronellal was determined to be 7000 μg/cm2. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; citronellal is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to citronellal is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; citronellal was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (ie, Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are< 1.