RNA splicing and cancer

E Wang, I Aifantis - Trends in cancer, 2020 - cell.com
… In this review, we discuss the various mechanisms by which cancer cells exploit RNA
splicing to promote tumor growth and the current therapeutic landscape for splicing-based …

Alternative RNA splicing and cancer

S Liu, C Cheng - Wiley Interdisciplinary Reviews: RNA, 2013 - Wiley Online Library
… Furthermore, alternatively spliced genes may … spliced isoforms in cancer. We will then
summarize our understanding of mechanisms by which alternative splicing is regulated in cancer

Aberrant RNA splicing in cancer and drug resistance

BD Wang, NH Lee - Cancers, 2018 - mdpi.com
RNA splicing is a common and driving event in cancersplicing events conferring drug/therapy
resistance in cancer … In this review, aberrant splicing events in cancer-associated genes, …

Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

A Sveen, S Kilpinen, A Ruusulehto, RA Lothe… - Oncogene, 2016 - nature.com
… an overview of aberrant RNA splicing and its regulation in cancer. We then focus on the
executors of the splicing process. Based on a comprehensive catalog of splicing factor encoding …

Aberrant RNA splicing in cancer

L Escobar-Hoyos, K Knorr… - Annual review of cancer …, 2019 - annualreviews.org
… disrupt splicing in patients with cancer. Here we review recent studies of global changes in
splicing in cancer, splicing regulation of mitogenic pathways critical in cancer transformation, …

RNA splicing dysregulation and the hallmarks of cancer

RK Bradley, O Anczuków - Nature Reviews Cancer, 2023 - nature.com
… cellular processes termed ‘cancer hallmarks’ as proposed by Weinberg and Hanahan 10,11
. … and the cancer relevance of RNA splicing. We discuss splicing regulatory alterations that …

Dysregulation and therapeutic targeting of RNA splicing in cancer

RF Stanley, O Abdel-Wahab - Nature cancer, 2022 - nature.com
RNA splicing across a variety of cancers. Alterations in the cancer genome and dysregulation
of RNA splicing factors lead to missplicing, splicing alteration-dependent gene expression …

Therapeutic targeting of RNA splicing in cancer

EA Bonner, SC Lee - Genes, 2023 - mdpi.com
splicing alterations contribute to disease pathogenesis. This review article will discuss our
current understanding of how aberrant RNA splicing … target RNA splicing for cancer treatment. …

RNA in cancer

GJ Goodall, VO Wickramasinghe - Nature Reviews Cancer, 2021 - nature.com
… While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA splicing

Splicing and cancer: Challenges and opportunities

PP Coltri, MGP Dos Santos… - … Reviews: RNA, 2019 - Wiley Online Library
… Many mutations found in diverse types of cancers are linked to alterations in splicing, either
… In this review, we will discuss the splicing mechanisms involved in cancer development, from …