Raman dye-labeled nanoparticle probes for proteins
Journal of the American Chemical Society, 2003•ACS Publications
In this paper, we demonstrate how one can chemically design Raman dye-functionalized
nanoparticle probes with specific protein-binding affinities and use these probes, coupled
with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed
screening of protein− small molecule interactions and protein− protein interactions in a
protein microarray format.
nanoparticle probes with specific protein-binding affinities and use these probes, coupled
with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed
screening of protein− small molecule interactions and protein− protein interactions in a
protein microarray format.
In this paper, we demonstrate how one can chemically design Raman dye-functionalized nanoparticle probes with specific protein-binding affinities and use these probes, coupled with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed screening of protein−small molecule interactions and protein−protein interactions in a protein microarray format.
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