Rapid and Cost-Efficient Detection of RET Rearrangements in a Large Consecutive Series of Lung Carcinomas
VI Tiurin, EV Preobrazhenskaya… - International Journal of …, 2023 - mdpi.com
RET-kinase-activating gene rearrangements occur in approximately 1–2% of non-small-cell
lung carcinomas (NSCLCs). Their reliable detection requires next-generation sequencing
(NGS), while conventional methods, such as immunohistochemistry (IHC), fluorescence in
situ hybridization (FISH) or variant-specific PCR, have significant limitations. We developed
an assay that compares the level of RNA transcripts corresponding to 5′-and 3′-end
portions of the RET gene; this test relies on the fact that RET translocations result in the …
lung carcinomas (NSCLCs). Their reliable detection requires next-generation sequencing
(NGS), while conventional methods, such as immunohistochemistry (IHC), fluorescence in
situ hybridization (FISH) or variant-specific PCR, have significant limitations. We developed
an assay that compares the level of RNA transcripts corresponding to 5′-and 3′-end
portions of the RET gene; this test relies on the fact that RET translocations result in the …
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