Rapid intrahost evolution of human cytomegalovirus is shaped by demography and positive selection

N Renzette, L Gibson, B Bhattacharjee, D Fisher… - PLoS …, 2013 - journals.plos.org
… of positive selection in shaping HCMV evolution is variable and dependent on context. Very
few putative targets of positive selection … of demography and selection to the evolutionary

Past and ongoing adaptation of human cytomegalovirus to its host

A Mozzi, M Biolatti, R Cagliani, D Forni… - PLoS …, 2020 - journals.plos.org
… are also known to frequently shape host-pathogen … GammaMap is relatively insensitive to
demography and recombination [… To identify sites evolving under positive selection on HCMV

Human cytomegalovirus intrahost evolution—a new avenue for understanding and controlling herpesvirus infections

N Renzette, L Gibson, JD Jensen, TF Kowalik - Current opinion in virology, 2014 - Elsevier
… population can rapidly evolve, either due to natural selection or … For other organisms, a positive
correlation has been shown … positive selection of beneficial alleles and negative selection

On the demographic and selective forces shaping patterns of human cytomegalovirus variation within hosts

AM Sackman, SP Pfeifer, TF Kowalik, JD Jensen - Pathogens, 2018 - mdpi.com
demographic, genetic, and selective forces that shape the … evolutionary forces of sufficient
strength to generate rapid … Conversely, genetic hitchhiking owing to positive selection

On the analysis of intrahost and interhost viral populations: human cytomegalovirus as a case study of pitfalls and expectations

N Renzette, SP Pfeifer, S Matuszewski… - Journal of …, 2017 - Am Soc Microbiol
… the demographic history of the … by rapid population growth (ie, population bottlenecks [7]).
The frequencies of observed polymorphisms are also shaped by the effects of direct selection, …

A consideration of within-host human cytomegalovirus genetic variation

JD Jensen, TF Kowalik - Proceedings of the National …, 2020 - National Acad Sciences
… of intrahost variation in human cytomegalovirus (HCMV) to be the result of exceptionally fast
… By modeling these selective and demographic processes jointly, ref. 10 demonstrated an …

[PDF][PDF] Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by

N Renzette, L Gibson, B Bhattacharjee, D Fisher… - 2013 - core.ac.uk
… the effect of positive selection in shaping HCMV evolution is … of demography and selection
to the evolutionary patterns … demography and positive selection influence the intrahost

Human cytomegalovirus haplotype reconstruction reveals high diversity due to superinfection and evidence of within-host recombination

J Cudini, S Roy, CJ Houldcroft… - Proceedings of the …, 2019 - National Acad Sciences
… to estimates of genome-wide intrahost diversity that rival those of … More recently, HCMV’s
rapid rate of recombination (9) … intrahost HCMV evolution, particularly in relation to HCMV

Within-host viral diversity: a window into viral evolution

AS Lauring - Annual Review of Virology, 2020 - annualreviews.org
… found a lack of evolutionary convergence (ie, positive selection) in viral sequences … Rapid
intrahost evolution of human cytomegalovirus is shaped by demography and positive selection

Islands of linkage in an ocean of pervasive recombination reveals two-speed evolution of human cytomegalovirus genomes

F Lassalle, DP Depledge, MB Reeves… - … evolution, 2016 - academic.oup.com
… of intense positive selection suggests that rapid evolution of … how recombination shapes
the diversity of HCMV genomes … cryptic differentiation to demographic or selective processes. …