Rare allelic forms of PRDM9 associated with childhood leukemogenesis
… childhood leukemia, we sought to type PRDM9 alleles in the parents of the B-ALL cohort. We
assayed PRDM9 ZnF alleles … 22 French-Canadian families with children affected by B-ALL (…
assayed PRDM9 ZnF alleles … 22 French-Canadian families with children affected by B-ALL (…
[PDF][PDF] Rare allelic forms of PRDM9 associated with childhood leukemogenesis
S Busche, L Holmfeldt, J Ma, CG Mullighan - 2012 - academia.edu
… childhood leukemia, we sought to type PRDM9 alleles in the parents of the B-ALL cohort. We
assayed PRDM9 ZnF alleles … 22 French-Canadian families with children affected by B-ALL (…
assayed PRDM9 ZnF alleles … 22 French-Canadian families with children affected by B-ALL (…
Whole-exome sequencing of a rare case of familial childhood acute lymphoblastic leukemia reveals putative predisposing mutations in Fanconi anemia genes
JF Spinella, J Healy, V Saillour, C Richer, P Cassart… - BMC cancer, 2015 - Springer
… and increased susceptibility to childhood ALL. Based on the … that inherited rare disadvantaging
DNA variants in leukemia … and, in combination with the rare allelic form of PRDM9, favour …
DNA variants in leukemia … and, in combination with the rare allelic form of PRDM9, favour …
[PDF][PDF] Rare allelic forms of PRDM9 associated with childhood
J Hussin, D Sinnett, F Casals - 2012 - academia.edu
… Because large-scale genomic rearrangements are common events in childhood leukemia,
we sought to type PRDM9 alleles in the parents of the B-ALL cohort. We assayed …
we sought to type PRDM9 alleles in the parents of the B-ALL cohort. We assayed …
[PDF][PDF] Rare allelic forms of
J Hussin, D Sinnett, F Casals - 2013 - academia.edu
… Because large-scale genomic rearrangements are common events in childhood leukemia,
we sought to type PRDM9 alleles in the parents of the B-ALL cohort. We assayed …
we sought to type PRDM9 alleles in the parents of the B-ALL cohort. We assayed …
Inherited Risk for Childhood Leukemia
… rare allele in the PRDM9 gene responsible for meiotic recombination [40]. The same PRDM9
allele … cohort of parents (N = 44) and childhood B-cell ALL patients (N = 50), suggesting that …
allele … cohort of parents (N = 44) and childhood B-cell ALL patients (N = 50), suggesting that …
Multifaceted role of PRDM proteins in human cancer
… of this protein in several leukemia subtypes are well … PRDM9 variability has been suggested
to influence genomic instability, the authors of this study argued that these rare allelic forms …
to influence genomic instability, the authors of this study argued that these rare allelic forms …
[HTML][HTML] Geographical genetic variability: a factor to consider when assessing clinical implications of PRDM9
A Alemany-Schmidt, M Navarro-Palou… - Molecular genetics & …, 2014 - ncbi.nlm.nih.gov
… in which an implication of PRDM9 is assumed. For example, a recent study (Hussin et al.
2013) associates rare allelic forms of PRDM9 with childhood leukemogenesis. The authors …
2013) associates rare allelic forms of PRDM9 with childhood leukemogenesis. The authors …
[HTML][HTML] Variation in the zinc finger of prdm9 is associated with the absence of recombination along nondisjoined chromosomes 21 of maternal origin
TR Oliver, C Middlebrooks, A Harden… - Journal of Down …, 2016 - ncbi.nlm.nih.gov
… PRDM9 ZFBD among mothers of children with Trisomy 21 in efforts to determine if variation
within this region is associated with the recombination-related … ZFBD allele, the allele type …
within this region is associated with the recombination-related … ZFBD allele, the allele type …
Differences in meiotic recombination rates in childhood acute lymphoblastic leukemia at an MHC class II hotspot close to disease associated haplotypes
… However, the intensity of this hotspot is strongly influenced by variation at PRDM9 (Figure …
of rare PRDM9 alleles in parents of children with ALL, combined with unusual recombination …
of rare PRDM9 alleles in parents of children with ALL, combined with unusual recombination …