Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents
European journal of medicinal chemistry, 2009•Elsevier
In the course of our studies on the isolation of bioactive compounds from the roots of
Moringa oleifera, a traditional herb in southeast Asia, rare aurantiamide acetate 4 and 1, 3-
dibenzyl urea 5 have been isolated and characterized. And also, this is the first report of
isolation from this genus. Isolated compound inhibited the production of TNF-α and IL-2;
further compound 5 showed significant analgesic activities in a dose dependant manner.
These findings may help in understanding the mechanism of action of this traditional plant …
Moringa oleifera, a traditional herb in southeast Asia, rare aurantiamide acetate 4 and 1, 3-
dibenzyl urea 5 have been isolated and characterized. And also, this is the first report of
isolation from this genus. Isolated compound inhibited the production of TNF-α and IL-2;
further compound 5 showed significant analgesic activities in a dose dependant manner.
These findings may help in understanding the mechanism of action of this traditional plant …
In the course of our studies on the isolation of bioactive compounds from the roots of Moringa oleifera, a traditional herb in southeast Asia, rare aurantiamide acetate 4 and 1,3-dibenzyl urea 5 have been isolated and characterized. And also, this is the first report of isolation from this genus. Isolated compound inhibited the production of TNF-α and IL-2; further compound 5 showed significant analgesic activities in a dose dependant manner. These findings may help in understanding the mechanism of action of this traditional plant leading to control of activated mast cells on inflammatory conditions like arthritis, for which the crude extract has been used.
Elsevier
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