Re: Long-term treatment with onabotulinumtoxinA results in consistent, durable improvements in health related quality of life in patients with overactive bladder
To the Editor: Ginsberg et al should be commended for their study of outcomes of repeat 100
U onabotulinumtoxinA (BTX-A) injections for overactive bladder (OAB). However, their report
excluded patients who elected dose escalation to 150 U. Earlier dose escalation studies
have suggested that 50 U is not effective compared to placebo. 1 Moreover, doses higher
than 150 U are associated with minimal incremental clinical benefits but significant
increases in post-void residual volume and rates of clean intermittent selfcatheterization …
U onabotulinumtoxinA (BTX-A) injections for overactive bladder (OAB). However, their report
excluded patients who elected dose escalation to 150 U. Earlier dose escalation studies
have suggested that 50 U is not effective compared to placebo. 1 Moreover, doses higher
than 150 U are associated with minimal incremental clinical benefits but significant
increases in post-void residual volume and rates of clean intermittent selfcatheterization …
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