A reactive oxygen species (ROS) responsive cleavable hierarchical metallic supra‐
nanostructure (HMSN) is reported. HMSN structured with thin branches composed of
primary gold (Au) nanocrystals and silver (Ag) nano‐linkers is synthesized by a one‐pot
aqueous synthesis with a selected ratio of Au/Ag/cholate. ROS responsive degradability of
HMSN is tested in the presence of endogenous and exogeneous ROS. Significant ROS‐
responsive structural deformation of HMSN is observed in the ROS exposure with hydrogen …

In article number 2202694, Dong-Hyun Kim and co-workers develop reactive oxygen
species (ROS)–responsive biodegradable metallic nanoparticles that can be used for
various biomedical applications. Given the challenges of non-biodegradability of potent
inorganic nanoparticles, the introduction of a ROS-responsive cleavable hierarchical
metallic supra-nanostructure provides an exciting opportunity for ROS cancer nanomedicine
and therapeutic delivery nanocarrier applications.