… an adaptive-protective signature in reactive astrocytes. For example, Nrf2 activation in
astrocytes may influence protein degradation pathways to boost astrocyte-mediated clearance of …

… Protective responses, whilst potentially serving to mitigate … be offset by other deleterious
changes to astrocytes occurring in … which have the potential to confer neuroprotective benefit. In …

… Apart from these detrimental functions, reactivated astrocytes … neurotrophic factors with
neuroprotective functions; protection … reactive PD astrocytes exhibited a more profound response …

… , all-inclusive diverse response of reactive astrocytes to CNS injury. … play after CNS injuries
as well as their implications on the … during this transition to the detrimental scar-forming state. …

… reasons why the reactive response of astrocytes in a disease … (170), and these neuroprotective
functions are even more … other situations, it might be detrimental. The latter can be the …

… stress responses, and neuroimmune cascades, astrocytes are well … morphological and
molecular signatures, as well as region- … and the detrimental effects of neural hyperexcitability. (C) …

… into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. … that abrogate detrimental
actions of reactive astrocytes, … Lastly, responses of reactive astrocytes may be maladaptive …

… response to pathological stimuli. The activation and differentiation of … , which also exert a
neuroprotective effect by ameliorating … in the differentiation of detrimental astrocyte subsets may …

… and increasingly well-defined reactive astrocyte states are … on neurons (purple arrows) can
be detrimental or supportive. … to define reactive astrocyte responses to inflammatory insults …

… molecular signatures for the beneficial and detrimental reactive … changes in response to
toxic materials, astrocytes show … Astrocytes are important for neuroprotection by generating …