Reactive oxygen and targeted antioxidant administration in endothelial cell mitochondria
Y O'Malley, BD Fink, NC Ross, TE Prisinzano… - Journal of biological …, 2006 - ASBMB
We used fluorescent probes and EPR to study the mechanism (s) underlying reactive
oxygen species (ROS) production by endothelial cell mitochondria and the action of
mitoquinol, a mitochondria-targeted antioxidant. ROS measured by fluorescence resulted
from complex I superoxide released to the matrix and converted to H 2 O 2. In contrast, EPR
largely detected superoxide generated at complex III and effluxed outward. ROS
fluorescence by mitochondria fueled by the complex II substrate, succinate, was substantial …
oxygen species (ROS) production by endothelial cell mitochondria and the action of
mitoquinol, a mitochondria-targeted antioxidant. ROS measured by fluorescence resulted
from complex I superoxide released to the matrix and converted to H 2 O 2. In contrast, EPR
largely detected superoxide generated at complex III and effluxed outward. ROS
fluorescence by mitochondria fueled by the complex II substrate, succinate, was substantial …
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