[HTML][HTML] Reactive oxygen species induction by cabazitaxel through inhibiting Sestrin-3 in castration resistant prostate cancer
T Kosaka, H Hongo, Y Miyazaki, K Nishimoto… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) production induced by taxanes in cancer cells may
influence the taxane-induced cell death or the drug resistance. We investigated the
correlation between the cytotoxic effect of taxanes and ROS production in human castration-
resistant prostate cancer (CRPC) cell lines. Three human prostate cancer cell lines were
treated with increasing concentrations of docetaxel or cabazitaxel in vitro. Cabazitaxel
showed significantly higher cytotoxic efficacy than docetaxel in human CRPC cells …
influence the taxane-induced cell death or the drug resistance. We investigated the
correlation between the cytotoxic effect of taxanes and ROS production in human castration-
resistant prostate cancer (CRPC) cell lines. Three human prostate cancer cell lines were
treated with increasing concentrations of docetaxel or cabazitaxel in vitro. Cabazitaxel
showed significantly higher cytotoxic efficacy than docetaxel in human CRPC cells …
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