Real-time tumor oxygenation changes after single high-dose radiation therapy in orthotopic and subcutaneous lung cancer in mice: clinical implication for stereotactic …
C Song, BJ Hong, S Bok, CJ Lee, YE Kim… - International Journal of …, 2016 - Elsevier
Purpose To investigate the serial changes of tumor hypoxia in response to single high-dose
irradiation by various clinical and preclinical methods to propose an optimal fractionation
schedule for stereotactic ablative radiation therapy. Methods and Materials Syngeneic Lewis
lung carcinomas were grown either orthotopically or subcutaneously in C57BL/6 mice and
irradiated with a single dose of 15 Gy to mimic stereotactic ablative radiation therapy used in
the clinic. Serial [18 F]-misonidazole (F-MISO) positron emission tomography (PET) imaging …
irradiation by various clinical and preclinical methods to propose an optimal fractionation
schedule for stereotactic ablative radiation therapy. Methods and Materials Syngeneic Lewis
lung carcinomas were grown either orthotopically or subcutaneously in C57BL/6 mice and
irradiated with a single dose of 15 Gy to mimic stereotactic ablative radiation therapy used in
the clinic. Serial [18 F]-misonidazole (F-MISO) positron emission tomography (PET) imaging …
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