Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin
I Pastan, V Chaudhary, D FitzGerald, J Batra - US Patent 6,099,842, 2000 - Google Patents
Single chain immunotoxins directed at the human transferrin receptor using PCR based
methods are described. Anti-TFR (Fv)-PE40 contains DNA for the antigen binding portion
(Fv) of a monoclonal antibody directed at the human trans ferrin receptor fused to the DNA
for a 40,000 molecular weight fragment of Pseudomonas exotoxin (PE40). In another fusion
protein, DT388-anti-TFR (Fv), DNA for the antigen binding portions of the anti-TFR antibody
has been fused to the DNA encoding a truncated form of Diphtheria toxin. In anti-TFR (Fv) …
methods are described. Anti-TFR (Fv)-PE40 contains DNA for the antigen binding portion
(Fv) of a monoclonal antibody directed at the human trans ferrin receptor fused to the DNA
for a 40,000 molecular weight fragment of Pseudomonas exotoxin (PE40). In another fusion
protein, DT388-anti-TFR (Fv), DNA for the antigen binding portions of the anti-TFR antibody
has been fused to the DNA encoding a truncated form of Diphtheria toxin. In anti-TFR (Fv) …
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