Redox manipulation of DNA binding activity and BuGR epitope reactivity of the glucocorticoid receptor
KA Hutchison, G Matić, S Meshinchi… - Journal of Biological …, 1991 - Elsevier
Treatment of the transformed glucocorticoid receptor with hydrogen peroxide promotes the
formation of disulfide bonds and inhibits the ability of the receptor to bind to DNA
(Tienrungroj, W., Meshinchi, S., Sanchez, ER, Pratt, SE, Grippo, JF, Holmgren, A., and Pratt,
WB (1987) J. Biol. Chem. 262, 6992-7000). It has not been determined whether the
inhibition of DNA binding activity is due to disulfide bonds formed within the DNA binding
domain or between the DNA binding domain and another region of the receptor. In this …
formation of disulfide bonds and inhibits the ability of the receptor to bind to DNA
(Tienrungroj, W., Meshinchi, S., Sanchez, ER, Pratt, SE, Grippo, JF, Holmgren, A., and Pratt,
WB (1987) J. Biol. Chem. 262, 6992-7000). It has not been determined whether the
inhibition of DNA binding activity is due to disulfide bonds formed within the DNA binding
domain or between the DNA binding domain and another region of the receptor. In this …
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