Importance Depressive severity is typically measured according to total scores on
questionnaires that include a diverse range of symptoms despite convincing evidence that
depression is not a unitary construct. When evaluated according to aggregate
measurements, treatment efficacy is generally modest and differences in efficacy between
antidepressant therapies are small. Objectives To determine the efficacy of antidepressant
treatments on empirically defined groups of symptoms and examine the replicability of these …