Reevaluation of dystrophin localization in the mouse retina
E Wersinger, A Bordais, Y Schwab… - … & visual science, 2011 - iovs.arvojournals.org
Purpose.: The roles of dystrophins in retinal physiology remain elusive. The lack of proper
clustering of the potassium channel Kir4. 1 and of the aquaporin AQP4 was proposed to be
the basis of the ERG abnormality observed in many Duchenne muscular dystrophy (DMD)
patients. However, the electroretinogram of Dp71-null mice, in which this clustering is
disrupted, shows only a moderate reduction of the b-wave with no change in the implicit
times. Additionally, the deficit in color discrimination found in DMD patients is hard to explain …
clustering of the potassium channel Kir4. 1 and of the aquaporin AQP4 was proposed to be
the basis of the ERG abnormality observed in many Duchenne muscular dystrophy (DMD)
patients. However, the electroretinogram of Dp71-null mice, in which this clustering is
disrupted, shows only a moderate reduction of the b-wave with no change in the implicit
times. Additionally, the deficit in color discrimination found in DMD patients is hard to explain …
[PDF][PDF] Reevaluation of Dystrophin Localization in the Mouse Retina
PURPOSE. The roles of dystrophins in retinal physiology remain elusive. The lack of proper
clustering of the potassium channel Kir4. 1 and of the aquaporin AQP4 was proposed to be
the basis of the ERG abnormality observed in many Duchenne muscular dystrophy (DMD)
patients. However, the electroretinogram of Dp71-null mice, in which this clustering is
disrupted, shows only a moderate reduction of the b-wave with no change in the implicit
times. Additionally, the deficit in color discrimination found in DMD patients is hard to explain …
clustering of the potassium channel Kir4. 1 and of the aquaporin AQP4 was proposed to be
the basis of the ERG abnormality observed in many Duchenne muscular dystrophy (DMD)
patients. However, the electroretinogram of Dp71-null mice, in which this clustering is
disrupted, shows only a moderate reduction of the b-wave with no change in the implicit
times. Additionally, the deficit in color discrimination found in DMD patients is hard to explain …
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