We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of
diverse ancestry, identifying 40 coding variant association signals (P< 2.2× 10− 7); of these…

… , just one variant in LD is sufficient, but to accurately fine-map it … Some regions can be refined
to a handful of variants (or indeed … enhancer mapping to identify likely target genes (31,32). …

… only 3 so refined using an earlier HapMap-based definition. … suggest that gains in fine-mapping
accuracy would be limited … -derived samples with valid diagnoses (healthy control, Crohn…

… We validate our findings using a large scale meta-analysis of … our method as way to refine
signal at known GWAS loci. This … accuracy for refining association signal through fine-mapping…

… prioritize candidates for functional validation. This subjective … to refine the most likely genetic
variants discovered by large-… for fine-mapping when the variants are accurately genotyped …

… of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with
associations attributable to coding … refine the mapping resolution at those loci where genetic …

… This uncertainty limits the accuracy of fine-mapping through … need to be refined and validated
using tissue- and cell-type-… genes will aid drug target identification for complex diseases. In …

… variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate
variants … the importance of fine-mapping studies and has implications for clinical risk profiling. …

… effective “precision” medicines; support identification of patient … variants, in fine-mapping
studies to fill in the pattern of genetic … focus on new, more refined phenotypes. With respect to …