[HTML][HTML] Regional TMPRSS2 V197M allele frequencies are correlated with COVID-19 case fatality rates
Coronavirus disease, COVID-19 (coronavirus disease 2019), caused by SARS-CoV-2
(severe acute respiratory syndrome coronavirus 2), has a higher case fatality rate in
European countries than in others, especially East Asian ones. One potential explanation for
this regional difference is the diversity of the viral infection efficiency. Here, we analyzed the
allele frequencies of a nonsynonymous variant rs12329760 (V197M) in the TMPRSS2 gene,
a key enzyme essential for viral infection and found a significant association between the …
(severe acute respiratory syndrome coronavirus 2), has a higher case fatality rate in
European countries than in others, especially East Asian ones. One potential explanation for
this regional difference is the diversity of the viral infection efficiency. Here, we analyzed the
allele frequencies of a nonsynonymous variant rs12329760 (V197M) in the TMPRSS2 gene,
a key enzyme essential for viral infection and found a significant association between the …
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