Context Cannabis is the most widely used illicit drug in the developed world. Despite this,
there is a paucity of research examining its long-term effect on the human brain. Objective
To determine whether long-term heavy cannabis use is associated with gross anatomical
abnormalities in 2 cannabinoid receptor–rich regions of the brain, the hippocampus and the
amygdala. Design Cross-sectional design using high-resolution (3-T) structural magnetic
resonance imaging. Setting Participants were recruited from the general community and …