Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies
RCA Sainson, AL Harris - Angiogenesis, 2008 - Springer
The notch-signalling pathway regulates cell fate and differentiation through cell–cell
communication. In recent years, several in vitro and in vivo studies have demonstrated that
notch-signalling functions as a negative feedback mechanism downstream of the VEGF-
signalling pathway that acts to finely shape the vascular network. Notch activation by the
Jagged-1 and Delta-like 4 ligands regulates different steps of blood vessel development
ranging from proliferation and survival of endothelial cells, to vessel branching and arterial …
communication. In recent years, several in vitro and in vivo studies have demonstrated that
notch-signalling functions as a negative feedback mechanism downstream of the VEGF-
signalling pathway that acts to finely shape the vascular network. Notch activation by the
Jagged-1 and Delta-like 4 ligands regulates different steps of blood vessel development
ranging from proliferation and survival of endothelial cells, to vessel branching and arterial …
Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies
C Richard, A Sainson, AL Harris - Angiogenesis, 2008 - search.proquest.com
The notch-signalling pathway regulates cell fate and differentiation through cellcell
communication. In recent years, several in vitro and in vivo studies have demonstrated that
notch-signalling functions as a negative feedback mechanism downstream of the VEGF-
signalling pathway that acts to nely shape the vascular network. Notch activation by the
Jagged-1 and Delta-like 4 ligands regulates different steps of blood vessel development
ranging from proliferation and survival of endothelial cells, to vessel branching and …
communication. In recent years, several in vitro and in vivo studies have demonstrated that
notch-signalling functions as a negative feedback mechanism downstream of the VEGF-
signalling pathway that acts to nely shape the vascular network. Notch activation by the
Jagged-1 and Delta-like 4 ligands regulates different steps of blood vessel development
ranging from proliferation and survival of endothelial cells, to vessel branching and …
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