Background: Normal cells are sensitive to anoikis, which is a cell detachment-induced
apoptosis. However, cancer cells acquire anoikis resistance that is essential for successful
metastasis. This study aimed to demonstrate the function and potential mechanism of
NADPH oxidase 4 (NOX4) and EGFR activation in regulating anoikis resistance in lung
cancer. Methods: Cells were cultured either in the attached or suspended condition. Cell
viability was measured by cell counting and live and dead cell staining. Expression levels of …

Anoikis is a kind of apoptosis caused by inappropriate interaction between cells and
extracellular matrix (ECM). Anoikis is essential process for maintaining appropriate number
of cells in epithelial tissues. Normal cells are sensitive to anoikis whereas cancer cells
acquire the anoikis resistance and survive when they detached from ECM. Anoikis
resistance has an effect on proliferation and adhesion, and motility of cancer cells, also it is
important for metastasis of cancer cells, especially. To investigate anoikis resistance …