Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52)
The large FK506-binding protein FKBP52 has been characterized as an important positive
regulator of androgen, glucocorticoid and progesterone receptor signaling pathways.
FKBP52 associates with receptor–Hsp90 complexes and is proposed to have roles in both
receptor hormone binding and receptor subcellular localization. Data from biochemical and
cellular studies have been corroborated in whole animal models as fkbp52-deficient male
and female mice display characteristics of androgen, glucocorticoid and/or progesterone …
regulator of androgen, glucocorticoid and progesterone receptor signaling pathways.
FKBP52 associates with receptor–Hsp90 complexes and is proposed to have roles in both
receptor hormone binding and receptor subcellular localization. Data from biochemical and
cellular studies have been corroborated in whole animal models as fkbp52-deficient male
and female mice display characteristics of androgen, glucocorticoid and/or progesterone …
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