Regulatory B cells in rheumatoid arthritis: alterations in patients receiving anti-TNF therapy
Z Bankó, J Pozsgay, T Gáti, B Rojkovich, I Ujfalussy… - Clinical …, 2017 - Elsevier
Cytokines, including tumor necrosis factor alpha (TNFα) are involved in Rheumatoid arthritis
(RA) pathogenesis by augmenting autoimmunity, sustaining long term inflammation in the
synovium, and promoting joint damage. Anti-TNF therapy is one of the most efficient and
widely used therapies for RA, although its mechanism is not clarified yet. Earlier we
demonstrated that RA patients have a reduced number of IL-10 producing regulatory B cells
(B10 cells) as compared to healthy individuals and they are functionally impaired. Our aim …
(RA) pathogenesis by augmenting autoimmunity, sustaining long term inflammation in the
synovium, and promoting joint damage. Anti-TNF therapy is one of the most efficient and
widely used therapies for RA, although its mechanism is not clarified yet. Earlier we
demonstrated that RA patients have a reduced number of IL-10 producing regulatory B cells
(B10 cells) as compared to healthy individuals and they are functionally impaired. Our aim …
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