Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal
T Baumann, A Dunkel, C Schmid, S Schmitt… - Nature …, 2020 - nature.com
Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs),
populate inflamed or cancerous tissue and block immune cell effector functions. The lack of
mechanistic insight into MDSC suppressive activity and a marker for their identification has
hampered attempts to overcome T cell inhibition and unleash anti-cancer immunity. Here,
we report that human MDSCs were characterized by strongly reduced metabolism and
conferred this compromised metabolic state to CD8+ T cells, thereby paralyzing their effector …
populate inflamed or cancerous tissue and block immune cell effector functions. The lack of
mechanistic insight into MDSC suppressive activity and a marker for their identification has
hampered attempts to overcome T cell inhibition and unleash anti-cancer immunity. Here,
we report that human MDSCs were characterized by strongly reduced metabolism and
conferred this compromised metabolic state to CD8+ T cells, thereby paralyzing their effector …
[引用][C] Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal
T Baumann, A Dunkel, C Schmid, S Schmitt… - 2021 - mediatum.ub.tum.de
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Gesamtbestand Hochschulbibliographie Elektronische Prüfungsarbeiten Open Access
Publikationen Forschungsdaten TUM.University Press Sammlungen Projekte Einrichtungen
Forschungszentren Hochschulpräsidium Hochschulreferate Partnerschaftliche
Einrichtungen Schools TUM School of Computation, Information and Technology (44340) …
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