We would like to thank the discussants for their insight and efforts in producing this entertaining and thoughtful discussion. We believe that they have raised interesting points regarding our analysis and have made valuable contributions that suggest ways to build on our original idea. Our response focuses on four main points:(1) incorporating data into the discussion,(2) the importance of reproducible research,(3) a new statistical formulation for the science-wise false discovery rate (SWFDR), and (4) are most published medical results “true”?