The purpose of this study to investigate the relationship between Body Mass Index (BMI) and depression and mental health status in nursing students of the Jiroft nursing college. This is a descriptive-analytic study, conducted on a group of 173 nursing students of the Jiroft nursing college in 1387. Data were collected using a demographic questionnaire, the Beck Inventory depression and General Health Questionnaire (GHQ). Weight and height were measured without shoes and wearing light clothes. BMI was calculated by kg/m2. SPSS software and t test, Pearson correlation, Chi-score and logistic regression was used for data analysis. Of the total population, 77/4% of samples were female and 22/6% were male. The mean age of samples was 21±1/9, mean BMI was 22/4±3/5. 16.6% of subjects were low weight, 10.6% over weight and 2.3% were obese. Data revealed a significant positive correlation between depression scores and body mass index scores (R=0/204, P<0/01). There was not significant correlation between GHQ and body mass index scores (R=0/108, P>0/157). Data also revealed that BMI is significantly related to depression [OR=1/1 CI 95%=1/02-1/20] and place of residence [OR=6/86 CI 95%=2/38-19/78] among females, but not in males. It seems that enhancing mood and mental health status can reduce overweight in female nursing students of the Jiroft nursing college.