Human exposure to multiple chemicals compromises the integrity of genetic material.
Hence, it is essential to determine the extent of DNA damage induced by xenobiotics. In cell
lines, the induction of p53 expression in response to treatments with DNA-damaging agents
has been proposed as a tool for the detection of genotoxic damage, although a direct
correlation between a marker of chromosomal damage and p53 expression has not
previously been studied. The micronucleus assay is a widely used genotoxicity test that has …