In patients with β-thalassemia major, the most important cause of mortality and morbidity is
organ failure due to deposits of iron.. In this study, the nature of the kidney injury and
possible pathogenetic factors were investigated. Seventy children with β-thalassemia major
and 14 age and sex-matched healthy children were involved in the study. Blood and timed
urine samples were obtained for hematological and biochemical tests. The mean values of
blood urea nitrogen (BUN), serum creatinine, creatinine clearance, serum sodium, urine …

Background In β-thalassemia, profound anemia and severe hemosiderosis cause functional
and physiological abnormalities in various organ systems. In recent years, there have been
few published studies mainly in adult demonstrating renal involvement in β-thalassemia.
This prospective study was aimed to investigate renal involvement in pediatric patients with
transfusion dependant beta-thalassemia major (TD-βTM), using both conventional and early
markers of glomerular and tubular dysfunctions, and to correlate findings to oxidative stress …