Renieramycin J, a Highly Cytotoxic Tetrahydroisoquinoline Alkaloid, from a Marine Sponge Neopetrosia sp.
Journal of natural products, 2003•ACS Publications
Renieramycin J (1), a new tetrahydroisoquinoline alkaloid, has been isolated from a marine
sponge Neopetrosia sp. as a potent cytotoxin that induced morphological changes in 3Y1
cells. Such changes are characteristic of RNA and/or protein synthesis inhibitors. The
structure of 1 including the absolute stereochemistry was determined by spectroscopic and
chemical methods.
sponge Neopetrosia sp. as a potent cytotoxin that induced morphological changes in 3Y1
cells. Such changes are characteristic of RNA and/or protein synthesis inhibitors. The
structure of 1 including the absolute stereochemistry was determined by spectroscopic and
chemical methods.
Renieramycin J (1), a new tetrahydroisoquinoline alkaloid, has been isolated from a marine sponge Neopetrosia sp. as a potent cytotoxin that induced morphological changes in 3Y1 cells. Such changes are characteristic of RNA and/or protein synthesis inhibitors. The structure of 1 including the absolute stereochemistry was determined by spectroscopic and chemical methods.
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