Renin–Angiotensin system and fibrinolytic pathway in COVID-19: One-way skepticism

HM Al-Kuraishy, NR Hussien, MS Al-Naimi… - Biomedical and …, 2020 - journals.lww.com
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection is a recent
pandemic infectious disease caused by severe acute respiratory syndrome coronavirus
(SARS-CoV-2). The entry point of SARS-CoV-2 is via angiotensin-converting enzyme 2
(ACE2), which is highly expressed in the alveolar pulmonary cells. Besides, different
peptides and co-mediators such as bradykinin (BK), plasmin, and trans-membrane serine
protease may modulate the affinity and binding of SARS-CoV-2 to ACE2. Therefore, this …
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