The study was conducted to determine the response in growth performance, physicochemical properties and fatty acid composition of broiler meat fed incremental levels of M. pruriens seed meal. A total of 112 Cobb 500, seven days old, unsexed broiler chicks with body weight of 150±5.47 g/bird (mean±SD) were used. Chicks were allotted to pens in a completely randomized design hence assigned to four experimental diets containing 0, 10, 15, and 20% of MPSM, respectively. Each diet was offered ad libitum with clean water to 28 broilers in each treatment. There was a linear decrease in average daily feed intake (ADFI), average daily gain (ADG) and final body weight (FBW) with incremental levels of MPSM (P< 0.05). Feed conversion ratio (FCR) increased linearly with increasing MPSM levels while Final Body Wight (FBW) decreased linearly with increasing levels of MPSM (P< 0.05). Meat pH 24 and colour parameters showed no relationship with increasing levels of MPSM (P> 0.05). Thawing loss, carcass weight and cooking loss showed a linear increase with increasing levels of MPSM (P< 0.05). However, shear force showed a linear decrease with increasing levels of MPSM (P> 0.05). Muscle fat, fat free dry matter (FFDM) and moisture, mono-unsaturated fatty acids and margaric acid showed no relationship with increasing levels of MPSM (P> 0.05), however, a linear decrease (P< 0.05) on myristic acid and palmitic acid with incremental levels of MPSM was observed. Arachidic acid, and α-Linolenic acid increased linearly with inclusion level of MPSM (P< 0.05). Other poly-unsaturated fatty acids, fatty acid ratios and health lipid indices indicators showed no relationship with increasing levels of MPSM (P> 0.05). Increasing inclusion levels of MPSM impairs growth performance of broilers and may also improve broiler quality and fatty acid some fatty acids.