… persistent spatiotemporal control of induced protein degradation that … (photoPROTACs) by
including ortho-F 4 -azobenzene linkers between both warhead ligands. This highly bistable …

… First, unlike typical reversible enzymatic inhibitors, active center or allosteric site of … In
contrast with PHOTACs, photoPROTACs remains as cis inactive form at beginning, and could be …

… the precise temporal and spatial control of protein levels, … as well, provided they are bistable
and can be fully turned off … of the active species can be reversibly tuned through the color …

… degradation of protein targets in a spatiotemporal … -inducible protein degradation. These
opto-PROTACs display no activities in the dark, while the restricted degradation can be induced …

… controlling spatial and temporal target protein degradation (… incomplete reversibility in
cis–trans photoisomerization.[202] … , and used for designing bistable photoPROTACs. Ortho-F4-…

… allow the noninvasive spatiotemporal control of proteolysis, … have been devised to
accomplish such reversible control. … Compound 9 was reported as bistable since thermal back …

… Our lead compounds display little or no activity in the dark but can be reversibly activated …
strategy to control targeted protein degradation with the temporal and spatial precision that …

… induce protein degradation with light was established to augment the chemists’ toolbox to
study disease-relevant protein … Light with high spatiotemporal resolution has been widely used …

… PROTAC 4, degradation of GFP … control induced degradation of a target protein. Together,
these results successfully demonstrate the ability to conditionally control protein degradation …

… reported bistability was retained in the photoPROTAC-1, and … of photoPROTAC-1, and
reversed protein degradation activity … reversible spatiotemporal control over protein degradation. …