The endocrine pancreas consists of approximately 1 million islets of Langerhans interspersed throughout the pancreatic gland. Within the islets, at least four hormoneproducing cells are present. Their hormone products include insulin, islet amyloid polypeptide (IAPP, or amylin), whose metabolic function remains undefined glucagon, the hyperglycemic factor that mobilizes glycogen stores; somatostatin, a universal inhibitor of secretory cells, and pancreatic peptide enzyme, a small protein that facilitates digestive processes by a mechanism not yet clarified. The pathology of the pancreas and other related factors such as intake of some drugs such as corticosteroids could lead to diabetes (WHO, 1999). The basis of diabetes mellitus treatment and management includes patient education regarding the disease, physical exercise, dietary modulation, application of synthetic hypoglycemic agents such as sulfonylureas, biguanides, glucosidase inhibitors, and glinides, which are used as monotherapy or in combination to achieve better glycemic regulation and products from medicinal plants. Many of these oral antidiabetic agents have a number of serious adverse effects; the main disadvantage