RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro
Y Xia, X Cai, J Fan, L Zhang, Z Li, J Ren, G Wu… - Anti-Cancer …, 2017 - journals.lww.com
GTPase RhoA and its downstream Rho-associated coiled-coil-containing protein kinases
(ROCKs) are frequently overexpressed in human cancers. Inhibition of the RhoA/ROCK
pathway blocks angiogenesis mediated by the vascular endothelial growth factor, which led
us to investigate the role of this pathway in vasculogenic mimicry (VM)–a process by which
aggressive cancer cells form vessel-like structures that provide adequate blood supply for
tumor growth. We showed that the expression of RhoA and its effector kinases ROCK1/2 …
(ROCKs) are frequently overexpressed in human cancers. Inhibition of the RhoA/ROCK
pathway blocks angiogenesis mediated by the vascular endothelial growth factor, which led
us to investigate the role of this pathway in vasculogenic mimicry (VM)–a process by which
aggressive cancer cells form vessel-like structures that provide adequate blood supply for
tumor growth. We showed that the expression of RhoA and its effector kinases ROCK1/2 …
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