Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial

…, K Holm, P Aukrust, S Åkra, I Seljeflot, S Solheim… - …, 2021 - thelancet.com
… aimed to explore the effect of S.boulardii or the oral non-absorbable antibiotic rifaximin on
top of guideline-recommended treatment for HF with reduced ejection fraction. In this proof-of-…

Design of the GutHeart—targeting gut microbiota to treat heart failure—trial: a Phase II, randomized clinical trial

…, A Hovland, A Lorenzo, S Halvorsen… - … Heart Failure, 2018 - Wiley Online Library
… and favourably affect cardiac function. … rifaximin or the probiotic yeast Saccharomyces
boulardii (ATCC 74012), on top of recommended treatment for HF, improves LV ejection fraction (…

The interaction of gut microbiota and heart failure with preserved ejection fraction: from mechanism to potential therapies

W Yu, Y Jiang, H Xu, Y Zhou - Biomedicines, 2023 - mdpi.com
… For example, nitrofurantoin and rifaximin could promote the growth of probiotics in intestines
Patients with HF who were treated with S. boulardii for three months also showed significant …

Microbial translocation and cardiovascular disease states: Emphasis on chronic heart failure, diabetes and the metabolic syndrome

AO Awoyemi - 2021 - duo.uio.no
… with reduced ejection fraction: Results from the randomized GutHeart trial We could not
demonstrate any significant effect of rifaximin or S Boulardii intervention on LVEF. For rifaximin

Efficacy and Safety of a Probiotic Containing Saccharomyces boulardii CNCM I-745 in the Treatment of Small Intestinal Bacterial Overgrowth in Decompensated …

I Efremova, R Maslennikov, M Zharkova… - Journal of Clinical …, 2024 - mdpi.com
… Simpson’s disk method, and ejection fraction was … Saccharomyces boulardii CNCM I-745
in eradicating SIBO in cirrhosis was 80%, which coincides with the effectiveness of rifaximin (76…

The Role of Gut Microbiota and the Potential Effects of Probiotics in Heart Failure

C Petruzziello, A Saviano, LL Manetti, N Macerola… - Medicina, 2024 - mdpi.com
… The study found that specific probiotic strains led to an improvement in gut microbiota
composition, as well as an improvement in the left ventricular ejection fraction. Similarly, Moludi J. …

Modulating gut microbial metabolism in heart failure: Opportunities and challenges

WHW Tang, T Chaikijurajai - EBioMedicine, 2021 - thelancet.com
Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: results
… Three months’ treatment with Saccharomyces boulardii or rifaximin on top of SoC had no …

Probiotics as potential treatments to reduce myocardial remodelling and heart failure via the gut-heart axis: state-of-the-art review

M Karmazyn, XT Gan - Molecular and Cellular Biochemistry, 2023 - Springer
… improvement in ejection fraction in patients receiving the … In that study, NYHA Class II or
Class III heart failure patients (… antibiotic rifaximin or the probiotic Saccharomyces boulardii for a …

Targeting gut microbiota as a novel strategy for prevention and treatment of hypertension, atrial fibrillation and heart failure: current knowledge and future perspectives

OM Drapkina, AA Yafarova, AN Kaburova, AR Kiselev - Biomedicines, 2022 - mdpi.com
… function in well-treated HF with reduced ejection fraction [82]. All … in both rifaximin and
Saccharomyces boulardii groups. A possible explanation for the lack of clinical effect may be a low

Pathogenic gut flora in patients with chronic heart failure

E Pasini, R Aquilani, C Testa, P Baiardi, S Angioletti… - JACC: Heart Failure, 2016 - jacc.org
… The moderate to severe mitral regurgitation might explain why, in NYHA functional class
III to IV, there is the co-presence of a moderately reduced ejection fraction and a marginally …