Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation
ML Hansen, R Sørensen, MT Clausen… - Archives of internal …, 2010 - jamanetwork.com
Background Patients with atrial fibrillation (AF) often require anticoagulation and platelet
inhibition, but data are limited on the bleeding risk of combination therapy. Methods We
performed a cohort study using nationwide registries to identify all Danish patients surviving
first-time hospitalization for AF between January 1, 1997, and December 31, 2006, and their
posthospital therapy of warfarin, aspirin, clopidogrel, and combinations of these drugs. Cox
proportional hazards models were used to estimate risks of nonfatal and fatal bleeding …
inhibition, but data are limited on the bleeding risk of combination therapy. Methods We
performed a cohort study using nationwide registries to identify all Danish patients surviving
first-time hospitalization for AF between January 1, 1997, and December 31, 2006, and their
posthospital therapy of warfarin, aspirin, clopidogrel, and combinations of these drugs. Cox
proportional hazards models were used to estimate risks of nonfatal and fatal bleeding …
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