The progressive increase in sporadic renal cell carcinoma (RCC) observed in industrialized
countries supports the opinion that certain carcinogens present in the environment (tobacco
smoke, drugs, pollutants, and dietary constituents) may affect the occurrence and
progression of this disease in developing countries like India. The polymorphism of the
enzymes involved in metabolism of such environmental factors may, therefore, confer
variable propensity to RCC. The possible association between RCC and a polymorphism of …