[HTML][HTML] Rivaroxaban and apixaban induce clotting factor Xa fibrinolytic activity
RLR Carter, K Talbot, WS Hur, SC Meixner… - Journal of Thrombosis …, 2018 - Elsevier
Essentials• Activated clotting factor X (FXa) acquires fibrinolytic cofactor function after
cleavage by plasmin.• FXa‐mediated plasma fibrinolysis is enabled by active site
modification blocking a second cleavage.• FXa‐directed oral anticoagulants (DOACs) alter
FXa cleavage by plasmin.• DOACs enhance FX‐dependent fibrinolysis and plasmin
generation by tissue plasminogen activator. Acknowledgements This research was funded
by the Heart and Stroke Foundation of Canada (ELG Pryzdial; G‐13‐0001644), by a …
cleavage by plasmin.• FXa‐mediated plasma fibrinolysis is enabled by active site
modification blocking a second cleavage.• FXa‐directed oral anticoagulants (DOACs) alter
FXa cleavage by plasmin.• DOACs enhance FX‐dependent fibrinolysis and plasmin
generation by tissue plasminogen activator. Acknowledgements This research was funded
by the Heart and Stroke Foundation of Canada (ELG Pryzdial; G‐13‐0001644), by a …
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