Role of TLR2-and TLR4-mediated signaling in Mycobacterium tuberculosis-induced macrophage death
D Sánchez, M Rojas, I Hernández, D Radzioch… - Cellular …, 2010 - Elsevier
Infection of macrophages with Mycobacterium tuberculosis (Mtb) induces cell death by
apoptosis or necrosis. TLRs 2 and 4 recognition of mycobacterial ligands has been
independently associated to apoptosis induction. To try to understand the particular
contribution of these receptors to apoptotic or necrotic signaling upon infection with live Mtb
H37Rv, we used macrophage lines derived from wild-type or TLR2-, TLR4-, and MyD88-
deficient mouse strains. Mtb-infection triggered apoptosis depending on a …
apoptosis or necrosis. TLRs 2 and 4 recognition of mycobacterial ligands has been
independently associated to apoptosis induction. To try to understand the particular
contribution of these receptors to apoptotic or necrotic signaling upon infection with live Mtb
H37Rv, we used macrophage lines derived from wild-type or TLR2-, TLR4-, and MyD88-
deficient mouse strains. Mtb-infection triggered apoptosis depending on a …
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