Role of ceramide in TNF-α-induced impairment of endothelium-dependent vasorelaxation in coronary arteries
The present study tested the hypothesis that ceramide, a sphingomylinase metabolite,
serves as an second messenger for tumor necrosis factor-α (TNF-α) to stimulate superoxide
production, thereby decreasing endothelium-dependent vasorelaxation in coronary arteries.
In isolated bovine small coronary arteries, TNF-α (1 ng/ml) markedly attenuated vasodilator
responses to bradykinin and A-23187. In the presence of N G-nitro-l-arginine methyl ester,
TNF-α produced no further inhibition on the vasorelaxation induced by these vasodilators …
serves as an second messenger for tumor necrosis factor-α (TNF-α) to stimulate superoxide
production, thereby decreasing endothelium-dependent vasorelaxation in coronary arteries.
In isolated bovine small coronary arteries, TNF-α (1 ng/ml) markedly attenuated vasodilator
responses to bradykinin and A-23187. In the presence of N G-nitro-l-arginine methyl ester,
TNF-α produced no further inhibition on the vasorelaxation induced by these vasodilators …
ROLE OF CERAMIDE IN TNF-α-INDUCED IMPAIRMENT OF ENDOTHELIUM-DEPENDENT VASORELAXATION IN SMALL BOVINE CORONARY ARTERIES
DX Zhang, FX Yi, AP Zou, PL Li - journals.physiology.org
The present study tested the hypothesis that ceramide, a sphingomylinase metabolite,
serves as an second messenger for TNF-α to stimulate superoxide production, thereby
decreasing endothelium-dependent vasorelaxation in coronary arteries. In isolated bovine
small coronary arteries, TNF-α (1 ng/ml) markedly attenuated vasodilator responses to
bradykinin and A23187. In the presence of NG-nitro-L-arginine methyl ester, TNF-α
produced no further inhibition on the vasorelaxation induced by these vasodilators. Using …
serves as an second messenger for TNF-α to stimulate superoxide production, thereby
decreasing endothelium-dependent vasorelaxation in coronary arteries. In isolated bovine
small coronary arteries, TNF-α (1 ng/ml) markedly attenuated vasodilator responses to
bradykinin and A23187. In the presence of NG-nitro-L-arginine methyl ester, TNF-α
produced no further inhibition on the vasorelaxation induced by these vasodilators. Using …
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