Role of mitochondrial complex IV in age-dependent obesity
I Soro-Arnaiz, QOY Li, M Torres-Capelli… - Cell reports, 2016 - cell.com
Aging is associated with progressive white adipose tissue (WAT) enlargement initiated early
in life, but the molecular mechanisms involved remain unknown. Here we show that
mitochondrial complex IV (CIV) activity and assembly are already repressed in white
adipocytes of middle-aged mice and involve a HIF1A-dependent decline of essential CIV
components such as COX5B. At the molecular level, HIF1A binds to the Cox5b proximal
promoter and represses its expression. Silencing of Cox5b decreased fatty acid oxidation …
in life, but the molecular mechanisms involved remain unknown. Here we show that
mitochondrial complex IV (CIV) activity and assembly are already repressed in white
adipocytes of middle-aged mice and involve a HIF1A-dependent decline of essential CIV
components such as COX5B. At the molecular level, HIF1A binds to the Cox5b proximal
promoter and represses its expression. Silencing of Cox5b decreased fatty acid oxidation …