Role of nicotinamide (vitamin B3) in acetaminophen-induced changes in rat liver: Nicotinamide effect in acetaminophen-damged liver
YI Mahmoud, AA Mahmoud - Experimental and Toxicologic Pathology, 2016 - Elsevier
Acetaminophen is a widely used analgesic and antipyretic agent, which is safe at
therapeutic doses. However, overdoses of acetaminophen induce severe oxidative stress,
which leads to acute liver failure. Nicotinamide has proven effective in ameliorating many
pathological conditions that occur due to oxidative stress. This study verifies the prophylactic
and therapeutic effects of nicotinamide against the hepatic pathophysiological and
ultrastructural alterations induced by acetaminophen. Wistar rats intoxicated with an acute …
therapeutic doses. However, overdoses of acetaminophen induce severe oxidative stress,
which leads to acute liver failure. Nicotinamide has proven effective in ameliorating many
pathological conditions that occur due to oxidative stress. This study verifies the prophylactic
and therapeutic effects of nicotinamide against the hepatic pathophysiological and
ultrastructural alterations induced by acetaminophen. Wistar rats intoxicated with an acute …
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